Regulation of anti-tumor responses by anticancer drugs through exosomes 1 Anticancer drugs cause release of exosomes with heat shock proteins from human hepatocellular carcinoma cells that elicit effective natural killer cell anti-tumor responses in vitro
نویسندگان
چکیده
From the ‡ Department of Hepatobiliary Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China, the § Thomas E Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15216, USA, the ¶ Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou 310003, China, the ‖ Department of General Surgery, General Hospital of Guangzhou Military Command of PLA, Guangzhou 510010, China
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The Role of Exosomes in Myeloid and Lymphoid Blood Malignancies: A Systematic Review Article
Background and Aim: Blood malignancies, one of the most common cancers in the world, cause a large number of deaths each year. Many inherited and acquired factors are involved in the development of this disease. Exosomes are a very small model of cells that are secreted by most cells in the body under physiological and pathological conditions. On the other hand, they have found a special place ...
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Detergent-soluble membrane vesicles are actively released by human pancreas (Colo /Colo+) and colon (CX /CX+) carcinoma sublines, differing in their capacity to present heat shock protein 70 (Hsp70)/Bag-4 on their plasma membranes. Floating properties, acetylcholine esterase activity, and protein composition characterized them as exosomes. An enrichment of Rab-4 documented their intracellular t...
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